You Should Be MAD at What They Told You About Ozempic

Summary: This video challenges the narrative that GLP-1 drugs like Ozempic are primarily weight-loss medications. Dr. Boz argues they are brain drugs with profound effects on metabolism, inflammation, and neurodegenerative disease prevention. Through case studies, science, and patient stories, she reveals how these drugs, combined with ketogenic diets, can supercharge brain repair, reduce amyloid plaque (linked to Alzheimer's), and improve long-term health. Key takeaways include the importance of ketones in circulation, the role of autophagy (cellular cleanup), and the dangers of insulin resistance.

---

1. Intro: The New Brain Drug?

Dr. Boz opens by criticizing the media's focus on GLP-1 drugs as weight-loss tools, calling it a "severe injustice." She emphasizes their neuroprotective potential, particularly when combined with ketogenic diets.

"This should have never been sold to you as a weight loss drug. It should be sold as a brain drug."

She shares her personal metrics: ketones of 2.1 and glucose of 87, highlighting her commitment to metabolic health.

---

2. History Lesson of GLP-1/GIP Drugs

The Evolution of GLP-1 Medications

• 2013: First GLP-1 drug (Bydureon) approved for diabetes, with minimal weight-loss effects.
• 2017–2019: Ozempic (semaglutide) gained popularity, but its brain benefits were overlooked.
• 2025: Over a decade of safety data confirms GLP-1 drugs are safe for long-term use, with millions of patients benefiting.

Generations of GLP-1 Drugs

1. First-gen: GLP-1 agonists (e.g., Ozempic).
2. Second-gen: GLP-1 + GIP agonists (e.g., tirzepatide/Zeppbound).
3. Third-gen: GLP-1 + GIP + glucagon agonists (coming soon).

"The third generation will be written by psychiatrists because of its brain-healing potential."

---

3. GLP-1 vs. Gastric Bypass

Dr. Boz argues that GLP-1 drugs are a safer alternative to gastric bypass surgery. While surgery removes stomach cells and risks nutrient deficiencies, GLP-1 drugs:

• Preserve gut function and nutrient absorption.
• Target root causes of metabolic disease (e.g., insulin resistance).
• Avoid lifelong complications like brain health decline.

"I hope I never recommend gastric bypass again. GLP-1 drugs are a way better brain drug than they were ever a weight-loss drug."

---

4. Ketones as Brain Fuel

Short-Term vs. Long-Term Benefits

• Short-term: Ketones provide clean energy, reducing brain inflammation and improving focus.
• Long-term: Ketones repair mitochondria (cell powerhouses) and reduce amyloid plaque (linked to Alzheimer's).

Case Study: Willie (10-Year-Old from Honduras)

• Survives on minimal food, leading to nightly ketosis.
• His brain develops better than nutrient-rich American children due to clean fuel and low inflammation.

"When you switch from glucose to ketones, two-thirds of your brain reactivates. The other third was offline."

---

5. Ian's Case: GLP-1 + Ketones for Brain Healing

Background

• Ian, 72, had 60 years of insulin resistance and 75 lbs of excess weight.
• After adopting a ketogenic diet, he lost weight but noticed persistent brain fog.

Intervention

• Added tirzepatide (GLP-1 + GIP) to his regimen.
• Results:
  • Ketones rose to 5.8 (from 1.1).
  • Glucose stabilized at 76–100.
  • Personality improvements: Reduced social anxiety, clearer speech.

"When I'm on GLP-1, that public speaking gut feeling I've always had—it's gone."

Science Behind the Success

• Autophagy: GLP-1 + ketones supercharge cellular cleanup, removing amyloid plaque.
• Lipolysis: Fat cells release stored energy, fueling brain repair.
• Amyloid Reduction: GLP-1 lowers amyloid production by 11% (per 2025 studies).

---

6. Micro-Dosing GLP-1 & The Numbers

Key Principles

• Ketones first: GLP-1 only works effectively with a bed of ketones.
• Dosing strategy: Micro-dosing (e.g., 2.5 mg weekly) avoids GI side effects and maximizes brain benefits.
• Timing: Administer GLP-1 after fasting to enhance autophagy.

"Adding GLP-1 to ketones is like giving your brain a supercharged cleanup crew."

---

7. Q&A Highlights

Q1: Is Prolonged Fasting Better Than GLP-1?

• Answer: Fasting alone may not provide enough GLP-1 stimulation for brain repair. Ketones + GLP-1 create a synergistic effect.

Q2: How Long Should I Micro-Dose for Brain Healing?

• Answer: Long-term use (years) may be needed for significant amyloid reduction. Personalized dosing is key.

Q3: Can GLP-1 Help with Lymphedema?

• Answer: Yes, by improving fat cell receptiveness and reducing inflammation. Start with ketosis, then add GLP-1.

Q4: Is Carnivore or Keto Better for Type 2 Diabetes?

• Answer: Focus on ketones in circulation, not diet labels. Both can work if they sustain ketosis.

---

Conclusion

Dr. Boz's message is clear: GLP-1 drugs are revolutionary for brain health, not just weight loss. Combining them with ketogenic diets can:

• Reverse insulin resistance.
• Clean up amyloid plaque.
• Preserve cognitive function long-term.

"You should be angry that you haven't heard more about this. This isn't just about losing weight—it's about saving your brain."

For those ready to dive deeper, Dr. Boz's 21-Day Metabolic Kickstart course offers personalized guidance on ketosis, GLP-1 dosing, and metabolic repair. 🧠✨