Why I'm Using Methylene Blue for My Metabolism

Brief Summary

Dr. Boz explores the science and personal use of methylene blue, a compound with historical and modern applications in metabolism, mitochondrial health, and disease treatment. She discusses its role as an antioxidant, its potential to combat free radicals, and its controversial reputation. The video covers dosing, safety (e.g., serotonin syndrome risks), and anecdotal benefits like joint pain relief. Dr. Boz shares her 3-week trial, emphasizing mitochondrial repair and metabolic optimization.

---

1. Introduction: Why Methylene Blue?

Dr. Boz begins by sharing her glucose (71 mg/dL) and ketone (2.7 mmol/L) levels, highlighting her fasted state (60 hours). She reveals her curiosity about methylene blue, sparked by public figures like RFK Jr. and historical uses:

"I started seeing a trend about methylene blue... why would he be doing that? It might have to do with his mitochondria or defense against viruses."

She acknowledges the compound's dual reputation: a potential metabolic aid and a controversial "blue dye." The talk promises to explore mechanisms, risks, and personal experiences.

---

2. Benefits & Historical Uses of Methylene Blue

Methylene blue has a rich history:

• Antidote for Poisoning: Used for cyanide, carbon monoxide, and methemoglobinemia (a blood disorder).
• Antimalarial Drug: Historically used to treat malaria and tuberculosis.
• Virus Fighter: Shown to disrupt viral replication and reduce oxidative stress.
• Pain Relief & Anti-Aging: Anecdotal reports suggest joint pain reduction and mitochondrial support for longevity.

"It's been around for a long time... known for cleansing, fighting viruses, and turning organs blue at autopsy."

Dr. Boz emphasizes its role in mitochondrial health, the powerhouses of cells critical for energy production.

---

3. How Methylene Blue Works in Mitochondria

The Science of Free Radicals & Methemoglobinemia

• Hemoglobin's Role: Iron in hemoglobin binds oxygen. When iron oxidizes (Fe³⁺), it forms methemoglobin, which can't carry oxygen.
• Methylene Blue's Fix: Converts Fe³⁺ back to Fe²⁺, restoring oxygen transport. This mechanism also applies to mitochondrial electron transport chains.

Mitochondrial Repair

Dr. Boz explains how dysfunctional mitochondria leak electrons, causing oxidative stress and inflammation. Methylene blue:

• Shuttles electrons to repair mitochondrial membranes.
• Reduces free radicals, slowing aging and metabolic damage.

"Mitochondria are amazing... the beauty is in their inner membrane where energy is made. Intact mitochondria shuffle protons efficiently."

She contrasts healthy (taut, folded) vs. damaged (deflated, leaky) mitochondria, linking dysfunction to chronic disease.

---

4. Clinical Observations: Dr. Boz's Personal Experience

After 3 weeks of use, Dr. Boz noticed:

• Reduced joint pain (e.g., thumb arthritis).
• Increased energy and mental clarity.
• Blue urine (a harmless side effect).

"I felt high... my speech was fast, and I had to walk off energy. It's like adding electrons to your mitochondrial membrane."

She cautions against expecting instant results: "If you took one dose and pain vanished, it was placebo. It takes 3–5 days to feel effects."

---

5. Does Methylene Blue Cause Serotonin Syndrome?

The Serotonin Syndrome Debate

• Monoamine Oxidase (MAO) Inhibition: Methylene blue inhibits MAO-A, which breaks down serotonin.
• Reversible vs. Irreversible: Unlike prescription MAO inhibitors (e.g., phenelzine), methylene blue's effects are reversible, lowering serotonin syndrome risk.

"Reversible MAO inhibitors are safer. Methylene blue doesn't stick permanently—pH or temperature changes undo it."

Dr. Boz advises caution if taking SSRIs/SNRIs but notes no major reports of toxicity at typical doses.

---

6. Dosing Guidelines

• Safe Range: 0.5–2 mg/kg body weight daily.
• Dr. Boz's Regimen: 10–20 drops (≈0.5 mg/kg) in water, taken morning with food to avoid stomach upset.
• Avoid Nighttime: May increase urination frequency.

"I chase it with sparkling water. It's bitter, but gets the job done."

She stresses consistency: "Give yourself 4 weeks of daily use to assess benefits."

---

7. Q&A Highlights

Key Questions Answered:

1. Joint Pain Relief:

   "Anecdotal reports suggest 3–7 days for pain reduction. It's not a magic pill, but mitochondrial repair takes time."

2. Drug Interactions:

   "Talk to your doctor if taking SSRIs/SNRIs. Methylene blue is reversible, but caution is wise."

3. Blueberries vs. Methylene Blue:

   "Hell yes, methylene blue is better. Blueberries have antioxidants, but eating a whole bowl spikes insulin and harms mitochondria."

4. Skin Infections:

   "It's antiseptic, but applying it directly would sting. Focus on internal use for metabolism."

---

Conclusion: Wrapping Up

Dr. Boz summarizes methylene blue as a tool for mitochondrial repair with historical credibility and modern potential. While not a cure-all, it may aid those with chronic inflammation, joint pain, or metabolic dysfunction. She emphasizes:

• Start low, monitor effects.
• Consult a doctor if on medications.
• Prioritize diet (e.g., ketogenic principles) for long-term mitochondrial health.

"Methylene blue isn't a replacement for a healthy lifestyle, but it's a fascinating addition to the toolkit."

For those intrigued, Dr. Boz shares her methylene blue product link and book recommendations in the video description. Stay tuned for future deep dives into metabolism and mitochondrial science! 🧬💙